Table 3.
Cognitive test scores at baseline (Session 1) and the post-open-label phase (Session 3, Week 26).
| POOLED DATA (n=10) | ||||||
|---|---|---|---|---|---|---|
| TEST | BASELINE MEAN (SD) | END OF OPEN LABEL MEAN (SD) | MEAN CHANGE (SD) | BASELINE MEDIAN (IQR) | END OF OPEN LABEL MEDIAN (IQR) | MEDIAN CHANGE (IQR) |
| 7–24 Spatial Recall Test | ||||||
| Learningt | 28.80 (5.12) | 32.20 (3.36) | 3.40 (5.36) | 28.00 (11.00) | 34.00 (7.00) | 5.00 (9.00) |
| Immediate Recall | 6.50 (0.71) | 6.50 (0.85) | 0.00 (1.16) | 7.00 (1.00) | 7.00 (1.00) | 0.00 (2.00) |
| Delayed Recall | 5.40 (1.96) | 6.60 (1.27) | 1.20 (2.44) | 6.00 (3.00) | 7.00 (0.00) | 0.00 (3.00) |
| Selective Reminding Test | ||||||
| LTS | 40.80 (13.03) | 50.10 (12.95) | 9.30 (12.73) | 49.00 (23.00) | 57.00 (23.00) | 7.00 (4.00) |
| CLTRa | 25.70 (11.04) | 40.30 (17.28) | 14.60 (14.59) | 34.00 (20.00) | 49.00 (41.00) | 8.00 (27.00) |
| Delayed Recall | 6.00 (3.59) | 7.10 (3.81) | 1.10 (3.11) | 9.00 (5.00) | 9.00 (6.00) | 1.00 (3.00) |
| Digit Span | 20.30 (4.62) | 20.60 (3.92) | 0.30 (2.95) | 19.00 (8.00) | 21.00 (7.00) | 1.00 (3.00) |
| Spatial Spanb | 13.60 (2.91) | 16.00 (2.83) | 2.40 (2.12) | 14.50 (6.00) | 17.00 (5.00) | 3.00 (2.00) |
| Block Design | 57.60 (6.04) | 58.40 (7.55) | 0.80 (6.36) | 57.50 (8.00) | 60.00 (12.00) | 0.50 (7.00) |
| Stroop Color Word Interference Testc | 125.99 (36.11) | 109.92 (27.67) | −16.07 (21.28) | 113.45 (60.50) | 104.90 (48.25) | −10.15 (13.98) |
| DKEFS Verbal Fluency | 100.50 (27.62) | 104.70 (28.68) | 4.20 (13.62) | 95.50 (44.00) | 107.50 (37.00) | 4.50 (23.00) |
| DKEFS Design Fluency | 29.20 (5.10) | 33.40 (9.01) | 4.20 (10.29) | 29.50 (10.00) | 34.00 (13.00) | 3.50 (11.00) |
| QOLIE Memoryd | 36.36 (18.36) | 47.89 (22.14) | 11.53 (10.54) | 27.78 (33.05) | 43.75 (42.99) | 9.87 (21.32) |
LTS = long-term storage; CLTR = continuous long-term retrieval; DKEFS = Delis–Kaplan Executive Functioning System; QOLIE = quality of life in epilepsy inventory.
Given the small number of subjects completing the open-label phase (n = 10, 3 of whom were originally assigned to memantine and 7 originally assigned to placebo), the data were pooled.
Significant change when post-open-label was compared with baseline:
p= 0.013,
p = 0.014,
p= 0.011,
p = 0.015.
A trend toward improvement was noted, 7/24 Spatial Recall Test learning score p = 0.07; SRT-LTS p = 0.06.
These improvements may be due to practice effects, the expectation of improvement, and/or multiple comparisons and should be interpreted with caution.