Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Apr 8;4(6):bvaa042. doi: 10.1210/jendso/bvaa042

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Endocrine Society 2020.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 4. — Assay for transposase-accessible chromatin using sequencing (ATAC-seq) analysis revealed apple- and pear-specific open chromatin regions in the gluteofemoral (GF) depot rather than in the abdominal (ABD) depot. A and B, Volcano plot representation of apple- (highlighted in red) and pear-specific (highlighted in blue) open chromatin regions in adipocyte fraction isolated from A, ABD and B, GF depot (P < .05). C and D, HOMER was used to annotate each identified open chromatin region to the closest gene using the hg19 reference genome. Open chromatin regions that could be annotated to differentially expressed genes (DEGs) are represented on the volcano: Open chromatin regions linked to apple- and pear-specific DEGs are highlighted in red and blue respectively in C, ABD and D, GF depots. Open chromatin regions that could not be linked to DEGs are represented in gray. E, Integrative Genomic Viewer (IGV) snapshot of ATAC-seq coverage in the GF depot representing 10 differentially opened chromatin regions (P < .05) between apple- and pear-shaped individuals associated with DEGs (false discovery rate < 0.05). The more accessible chromatin regions in apples are highlighted in red; more accessible regions in pears are highlighted in blue.