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. Author manuscript; available in PMC: 2020 May 30.
Published in final edited form as: J Cell Physiol. 2018 Sep 7;234(5):6244–6253. doi: 10.1002/jcp.27355

Figure 6. Mll2- and Mll3-COMPASS-like complexes are bound to the Runx2 P1 promoter in osteoblastic cells.

Figure 6.

Differentiated MC3T3 osteoblasts (A) and N2A neuronal cells (B) were analyzed by ChIP to determine the enrichment of Cgbp, Set1a, Set1b, Menin, Mll1, Mll2, Mll3, and Mll4 proteins at the Runx2 P1 promoter region (Runx2-P1, black) and at un upstream distal region (−5Kb) of Ric8b gene promoter (control region, white). The corresponding normal IgGs were used as specificity control during each chromatin precipitation experiment. Results are expressed as % Input ± SEM. For each immunoprecipitated sample the statistical analyses were performed with respect to the control region (*p<0.05, **p<0.01, ***p<0.001). Only significant differences are indicated in graphs.