Figure 5.

Schematic prediction of PC4 binding to PO DNA or to PS ASO. (A) PC4 complexed with PO DNA. (B) PC4 complexed with 5–10–5 PS OMe ASO. The protein PO DNA complex contains a single DNA molecule (blue) and a PC4 dimer. The protein PS ASO complex contains two ASOs and four protein molecules, with the 5′ portion of ASOs potentially base-paired based on this ASO used. Note that whether such duplex can form in biological systems needs to be investigated. The 2′ modified wings are shown in black, whereas the gap regions are in red.