Table 4.
PS ASO induced aggregates
| Aggregates | Protein compositions | Localization | Minimum transfected ASO concentration (nM) | Note |
|---|---|---|---|---|
| PS bodies | TCP1β, Mannosidase II | Nucleus | ∼20 | Upon Ran reduction, form in cytoplasm |
| Paraspeckle-like | P54nrb, PSF et al. | Nucleoplasm | ∼10 | No NEAT1 RNA |
| Nuclear filaments | P54nrb, PSF et al. | Nucleoplasm | ∼30–50 | No TDP43 |
| Loose nucleolar structures | P54nrb, PSF, NPM | Nucleolus | ∼15 | |
| Perinucleolar cap | P54nrb, PSF | Perinucleolar region | ∼40 | Toxic ASO |
| Stress granules | G3BP, mutant FUS, Mutant PSF | Cytoplasm | ∼50 | |
| P-bodies | DDX6, LSM14 et al. | Cytoplasm | ∼1 |