Table 5.

PS ASO interaction with model proteins

				ASO binding affinity
Protein	Feature	DNA/RNA binding domains	ASO binding domain	MOE	cEt	F
NCL	RNA binding	4	4	0.009	1.7	0.002
P54nrb	RNA/DNA binding	2	2	82.9	9.3	2.1
PSF	RNA.DNA binding	2	2	3.7	2.7	0.72
La	RNA binding	2	2	9.3	5.0	1.1
PC4	DNA binding	1	1	6.1	1.1	0.21
SSBP	DNA binding	1	1	0.36	0.77	0.04
RNase H1	DNA/RNA duplex binding	2 (duplex)	2	2	5	2

Adapted from Vickers TA., et al., PLoS One. 2016. 11(8):e0161930.