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SA1 and SA2 binding sites in vivo overlap significantly with R-loops. (A) ChIP-Seq pileup for CTCF, SA1, SA2, SMC1/SMC3 for four different cell lines (HCAEC, HMEC HeLa, and MCF10A). Peak pileup was calculated and visualized around the TSS for each cell line using the R package ChIPseeker. (B) Venn diagrams showing the overlap of SA1/SA2, cohesin SMC subunit (SMC1 or 3), CTCF and R-loop sites identified through DRIP-seq.
