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. 2020 May 4;48(10):5572–5590. doi: 10.1093/nar/gkaa302

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — REXO2 degrades nanoRNAs that may impair degradosome activity. (A) In vitro degradation of radiolabeled 17-nt-long, partially structured substrate by recombinant REXO2, mitochondrial degradosome (SUV3 and PNPase), and their combined action. REXO2_WT, wild-type REXO2; mut, catalytically inactive REXO2 (D47A D168A); no prot., no protein control. (B) In vitro degradation of tRNA-like oligonucleotide by the indicated proteins (abbreviations as in A) in the presence of an excess of nanoRNA (5RNA). (C) Quantification of tRNA-like decay that is shown in B. The data are expressed as the mean ± SEM of three independent experiments.