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. 2020 May 8;48(10):5201–5216. doi: 10.1093/nar/gkaa304

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 6. — Identification of putative alternative translation initiation sites (paTSS). (A) Distribution of HHT-identified paTSS. (B) Distribution of canonical initiation codons for HHT-identified paTSS. (C–H) Representative examples of paTSS identified in HHT-treated cells. (C) Intergenic smORF, (D) upstream smORF (uORF), (E) antisense translation initiation, (F) N-terminal extensions, (G) internal in-frame and (H) internal out-of-frame initiation. Plus strand is plotted with positive values and minus strand with negative values. Untreated samples are shown with gray bars on both strands, HHT conditions on the plus strand are red bars, and blue bars are HHT conditions on the minus strand.