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. 2020 Apr 27;48(10):5306–5317. doi: 10.1093/nar/gkaa223

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© The Author(s) 2020. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Directionality of transcribed enhancers is associated with CGIs. (A) Distribution of the directionality of 63 285 transcribed enhancers. (B) The absolute value of the directionality is significantly higher for enhancers that overlap with a CGI than for those that do not. (C) The overall CAGE tag count of enhancers associated with CGIs is higher for transcription in the direction of the CGI (same side) than on the opposite side of the enhancer.