Figure 14.

Two common mechanisms for designing drug-loaded CaP nanoparticles. Drugs can be entrapped inside micelles that act as templates for mineralization of CaP’s. Also, physical adsorption of drugs to CaP’s has been commonly used for synthesizing drug-loaded CaP’s. Schematic shows entrapment of Mitoxantrone (MIT) in PS-PEG-RGD micelles (Step 1). CaP shell was formed on the micelles to seal this drug (Step 2). A second drug (Verapamil or VER) was also added to the surface of CaP’s by mixing and physical adsorption (Step 3). RGD is a cancer targeting peptide. (Reprinted with permission from ref. [60]. Copyright 2018 WILEY-VCH Verlag GmbH & Co.)