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Schematic illustrating different CaP endocytic pathways. Nanoparticles are taken up into cancer cells via different routes including clathrin-dependent or clathrin-independent endocytosis (e.g., macropinocytosis, phagositosis and caveolae-mediated endocytosis). This process is highly complex and over 50 different proteins are participating in it. Intracellular trafficking and subsequent biological response depend on these pathways.
