Fig. 5.

Schematic of how DinJ impacts the general stress response. RpoS levels are reduced indirectly by DinJ through its control of cspE. Under erythromycin stress, DinJ is degraded by protease Lon, and cspE transcription is derepressed. The increased CspE levels lead to greater RpoS translation, which increases c-di-GMP concentrations, catalase activity and curli/cellulose production and decreases swimming. The lightning bolt indicates erythromycin stress, ‘→’ indicates induction and ‘⊥’ indicates repression.