Table 4.

Recommended start settings for AID mode (AnyDANA-loop)

AnyDANA-Loop Settings	Setting
Treatments Safety
Max allowed bolus	Set as the largest typical meal bolus for the participant or per investigator discretion. Note: If different to the pump’s max bolus, the lowest of the two will apply.
Max allowed carbs	Based on largest carb intake during run-in or discussion with participant.
Loop
APS mode	Open Loop (Stage 1).
Open APS 0.70
Max U/hr a temp basal can be set to	This acts as a safety parameter along with the safety multipliers. Can be set to 5x max daily basal to reduce likelihood of needing to increase it as safety multipliers are increased.
Max IOB	Set as the highest bolus from the previous two weeks + 2x their maximum daily basal or lower as per investigator and participant discretion.
Enable SMB	Set as ‘off’ by default at the start.
Advanced Settings
Max daily basal safety multiplier	Set as 3x the subject’s maximum daily basal rate (units/hour) or per investigator discretion. Note: If different to the pump’s max allowed basal, they will operate independently as limits.
Current basal safety multiplier	Set at 4x the current basal from the participant’s run-in period or RCT phase if the subject is switching from SAPT to AID for the continuation phase.
Absorption Settings
Minimum 5 min carbohydrate impact	Set to 8.
Max autosens ratio	Set to 1.2.
Min autosens ratio	Set to 0.8.
Other - Temp Targets
Activity duration	Set to 120 min.
Activity target	Set to target of 8.0.
Eating soon duration	Set to a duration of 60 min.
Eating soon target	Set to target of 4.5 mmol/L.
Hypo duration	The default setting is 30 min.
Hypo target	The default setting is 6.5 mmol/L.
Other - Alerts
Pump is unreachable	Set to on (default time is 30 min).