Table 3.
Performance characteristics of cerebrospinal fluid white blood cell count for predicting CSF and plasma HIV RNA discordance diagnosis
| HIV RNA | CSF>plasma [1] | CSF discordance [2] |
|---|---|---|
| CSF WBC [3] | >3.8 cell/mm3 | >15.0 cell/mm3 |
| Sensitivity | 75.00 | 100.00 |
| Specificity | 77.00 | 95.00 |
| PPV | 41.00 | 62.50 |
| NPV | 94.00 | 100.00 |
| Efficiency (test score) | 77.00 | 96.00 |
| Youden Index | 0.52 | 0.95 |
| LR+ | 3.23 | 21.00 |
| LR− | 0.33 | 0.00 |
| CUI+ | 0.31 | 0.63 |
| CUI− | 0.72 | 0.95 |
| AUC | 0.78 | 0.98 |
PPV, positive predictive value; NPV, negative predictive value; LR+, positive likelihood; LR−, negative likelihood; CUI+, Clinical utility index positive; CUI−, Clinical utility index negative; AUC, area under the receiver operating characteristic (ROC) curve.
[1]
HIV RNA higher than plasma, independent of the value of CSF or plasma HIV RNA.
[2]
CSF HIV RNA greater than 1log10 of the plasma viral load (VL) (Canestri et al. 2010)
[3]
Cut off points chosen by the ROC curve.