Table 3.
Regression results using rsFC for ACC and amygdala seed ROIs and depressive symptoms in AHI
| Seed ROI | Cluster location | MNI coordinates (x, y, z)a |
Cluster size (voxels) |
t-value | Average connectivityb AHI (n = 64) |
|---|---|---|---|---|---|
| Depressive Symptoms | |||||
| pgACC | n/a | -- | -- | -- | -- |
| Anterior sgACC | right precuneus | 7, −54, 38 | 442 | −5.04 | 6.47 |
| Posterior sgACC | left superior frontal gyrus | −23, 64, −12 | 682 | 5.80 | 6.44 |
| left precuneus | −1, −60, 52 | 660 | −5.95 | 1.09 | |
| right superior frontal gyrus | 25, 60, −14 | 331 | 6.60 | 7.32 | |
| right middle frontal gyrus | 45, 46, −14 | 302 | 6.47 | 8.94 | |
| left anterior cingulate | −9, 22, −8 | 192 | 6.12 | 17.61 | |
| left uncus | −39, −14, −44 | 178 | −5.33 | −2.71 | |
| right culmen | 45, −42, −34 | 159 | 5.49 | 6.84 | |
| left inferior parietal lobule | −33, −42, 56 | 153 | −5.05 | −1.65 | |
| L amygdala | left fusiform gyrus | −41, −64, −20 | 280 | 5.37 | −0.49 |
| right precuneus | 21, −50, 44 | 167 | −5.00 | −6.04 | |
| R amygdala | n/a | -- | -- | -- | -- |
Notes. AHI = Acute HIV, pgACC = pregenual anterior cingulate cortex, sgACC = subgenual anterior cingulate cortex, R = right, L = left. (pFWE = .01; uncorrected p = .001).
a
LPI coordinate order
b
Average connectivity of seed ROI to cluster location (t-values), without any covariates. There were no significant relationships between depressive symptoms and rsFC for the pgACC or R amygdala (pFWE > .01).