. Author manuscript; available in PMC: 2021 Jun 1.

Published in final edited form as: J Neurochem. 2020 Jan 10;153(5):631–649. doi: 10.1111/jnc.14934

Table 1.

Blood and brain Mn concentrations of animals at PND 24, 66, and ~590.

	Age (PND)	Control	25 mg Mn/kg/day		50 mg Mn/kg/day
	Age (PND)	Control	Early life	Lifelong	Early life	Lifelong
Blood	24	24.6 ± 1.21 (6)^{A, a}	NA	131 ± 22.7 (7) ^{B, a}	NA	231 ± 33 (7) ^{C, a}
	66	9.3 ± 0.59 (7) ^{A, b}	12.2 ± 0.69 (8) ^B	12.9 ± 0.86 (9) ^{B, b}	11.5 ± 0.57 (8) ^B	18.6 ± 1.9 (7) ^{C, b}
	590	5.66 ± 0.57 (5) ^{A, c}	6.98 ± 0.95 (11) ^A	21.9 ± 8.66 (9) ^{B, c}	8.28 ± 1.32 (8) ^AB	16.8 ± 1.83 (10) ^{C, b}
Brain	24	3.62 ± 0.13 (6) ^{A, a}	NA	6.49 ± 0.56 (7) ^{AB, a}	NA	11.5 ± 2.57 (6) ^{B, a}
	66	2.12 ± 0.060 (7) ^{A, b}	2.19 ± 0.031 (8) ^A	2.41 ± 0.045 (9) ^{BC, b}	2.26 ± 0.062 (8) ^AB	2.51 ± 0.068 (7) ^{C, b}
	590	1.82 ± 0.11 (6) ^{A, b}	2.20 ± 0.17 (12) ^A	2.19 ± 0.049 (10) ^{AB, b}	2.00 ± 0.086 (7) ^A	2.68 ± 0.11 (11) ^{C, b}

Data are mean ± SEM with group sizes in parentheses; blood Mn in ng/mL, brain Mn in μg/g dry weight. Uppercase superscripts: within an age group and tissue, treatment groups with different capital letters are statistically different from one another (p < 0.05), based on Wilcoxon / Kruskal-Wallis test. Lowercase superscripts: within a treatment group and tissue, values across ages with different lowercase superscripts are statistically different from one another. PND, postnatal day.