Table 2.
Change in HbA1c at 6 months and 12 months from baseline by drug class
| Overall | SU | DPP4i | TZD | SGLT2i | |
|---|---|---|---|---|---|
| At month 0 (latest value ≤ 6 months prior to 2L initiation) | |||||
| On second-line therapy, N | 7170 | 3521 | 2981 | 178 | 490 |
| With measurement HbA1c [%] | |||||
| N (%) | 7170 (100.00%) | 3521 (100.00%) | 2981 (100.00%) | 178 (100.00%) | 490 (100.00%) |
| HbA1c [%], mean (SD) | 8.34 (0.78) | 8.40 (0.78) | 8.26 (0.76) | 8.37 (0.81) | 8.38 (0.80) |
| HbA1c < 7.5%, N (%) | 944 (13.17%) | 398 (11.30%) | 460 (15.43%) | 24 (13.48%) | 62 (12.65%) |
| At month 6a | |||||
| On therapy, N | 6238 (87.00%) | 3103 (88.13%) | 2573 (86.31%) | 155 (87.08%) | 407 (83.06%) |
| With measurement | |||||
| N (%) | 4803 (77.00%) | 2371 (76.41%) | 2008 (78.04%) | 115 (74.19%) | 309 (75.92%) |
| HbA1c [%], mean (SD) | 7.33 (0.97) | 7.25 (1.01) | 7.42 (0.93) | 7.44 (0.91) | 7.38 (0.79) |
| HbA1c < 7.5%, N (%) | 3177 (66.15%) | 1663 (70.14%) | 1261 (62.80%) | 71 (61.74%) | 182 (58.90%) |
| Change at 6 months (for patients with recorded values at initiation and month 6) | |||||
| Mean △ HbA1c [%], (SD) | − 1.01 (0.98) | − 1.18 (1.05) | − 0.81 (0.89) | − 0.98 (0.82) | − 1.03 (0.86) |
| At month 12b | |||||
| On therapy, N | 5402 (75.34%) | 2750 (78.10%) | 2166 (72.66%) | 138 (77.53%) | 348 (71.02%) |
| With measurement | |||||
| N (%) | 4068 (75.31%) | 2059 (74.87%) | 1645 (75.95%) | 106 (76.81%) | 258 (74.14%) |
| HbA1c [%], mean (SD) | 7.44 (1.07) | 7.46 (1.12) | 7.43 (1.02) | 7.44 (1.20) | 7.29 (0.88) |
| HbA1c < 7.5%, N (%) | 2,522 (62.00%) | 1,247 (60.56%) | 1,034 (62.86%) | 67 (63.21%) | 174 (67.44%) |
| Change at 12 months (for patients with recorded values at initiation and month 12) | |||||
| Mean △ HbA1c [%], (SD) | − 0.88 (1.07) | − 0.97 (1.11) | − 0.74 (1.00) | − 0.99 (1.23) | − 1.08 (0.98) |
DPP4i dipeptidyl peptidase 4 inhibitor, HbA1 glycated haemoglobin, SD standard deviation, SGLT2i sodium-glucose transport protein 2 inhibitor, SU sulphonylurea, TZD thiazolidinedione
aClosest value to month 6, ± 3 months)
bClosest value to month 12, ± 3 months)