| 2021 will mark 100 years since the discovery of insulin. |
| Occurrence of hypoglycemia has resulted in sub-optimal use of insulin. |
| Insulin delivery devices have rapidly advanced in the past 2 decades. |
| A comprehensive review of the insulin delivery devices is presented in this article. |
| Advances in the technologies from syringes and pens to pumps and a do-it-yourself (DIY) artificial pancreas aim to accomplish 100% TIR and 0% time in hypoglycemia. |
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