Figure 4.

Body weight, systolic blood pressure, IGTT, and serum of Ang II of animals. (a) The body weight of animals in each group increased before 5 weeks of age and decreased after 8 weeks of age. No difference was observed among the groups (p > 0.05). (b) The systolic blood pressure increased to 200 mmHg at 4 weeks and maintained a steady state. No difference was observed among the groups (p > 0.05). (c) Intraperitoneal glucose tolerance of animals in each group has no differences, p > 0.05. (d) Serum Ang II level increased significantly in the HUA animal model, but catalase, PEG-SOD, and epalrestat did not decrease the Ang II concentration; there was no differences between the treatment groups and the HUA group, p > 0.05.