Figure 2.

LI13019F1 downregulates inflammatory modulators in vitro. (a) The bar diagram presents a dose-dependent inhibition of 5-lipoxygenase enzyme activity by LI13019F1 in ferrous oxidation-xylenol orange (FOX) assay. (b) The line graphs show dose-dependent reductions of LTB₄ and PGE₂ productions in A23187-induced human polymorphonuclear neutrophils (PMNs) and LPS-induced human peripheral mononuclear cells (PBMCs), respectively. (c) The bar graph presents dose-dependent reductions of TNF-α production in LPS-induced human PBMC, as indicated. Data show mean ± SD; n = 3.