Skip to main content
. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Am J Med Genet C Semin Med Genet. 2020 Jan 30;184(1):90–96. doi: 10.1002/ajmg.c.31768

FIGURE 1.

FIGURE 1

Examples of congenital heart disease phenotypes identified in newborn mice. (a) Compared to wildtype newborn mouse heart, mutants recovered in our forward-genetic ENU screen exhibit a spectrum of cardiac phenotypes including (b) hypoplastic left heart syndrome (HLHS) in which left sided heart structures including the left ventricle, aorta, and mitral valve are severely hypoplastic, (c) hypoplastic right heart syndrome (HRHS) in which right sided heart structures including the right ventricle, pulmonary artery, and tricuspid valve are hypoplastic, (d) transposition of the great arteries (TGA) in which the aorta arises from the right ventricle and the pulmonary artery arises from the left ventricle, (e) persistent truncus arteriosis (PTA) in which a single outflow tract arises from the heart, and (f) double outlet right ventricle (DORV) in which both the aorta and the pulmonary artery arise from the right ventricle. Ao, aorta; PA, pulmonary artery; RV, right ventricle; LV, left ventricle; VSD, ventricular septal defect. Scale bar represents 0.5 mm