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. Author manuscript; available in PMC: 2020 Dec 26.
Published in final edited form as: J Med Chem. 2019 Dec 10;62(24):11301–11323. doi: 10.1021/acs.jmedchem.9b01580

Figure 6.

Figure 6.

Summary of B-SERD in vitro activity. 2D growth inhibition in MCF7:WS8 (A) and MCF7:5C (B) cells as a result of treatment with 37d (green) or 2 (orange). Data normalized to vehicle, dimethyl sulfoxide (DMSO) (1.0) and no cells (0.0) shown as mean ± SEM, from three biological and analytical replicates. (C) ER level following treatment for 24 h with 37d or 2 evaluated by ICW. Data corrected to vehicle (1) and 1 μM 2 shown as mean ± SEM, from three biological and analytical replicates.