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. Author manuscript; available in PMC: 2020 Dec 26.
Published in final edited form as: J Med Chem. 2019 Dec 10;62(24):11301–11323. doi: 10.1021/acs.jmedchem.9b01580

Table 2.

Antiproliferative Activity of Azetidine Ligands in Breast Cancer Cellsa

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a

Potency was determined by DNA content after 4 or 6 days of incubation in MCF7:WS8 or MCF7:5C respectively, following treatment with B-SERDs. Signal was normalized to vehicle control.

b

IC50 > 100 nM; 45% inhibition at 1 μM. Data shown as mean ± SEM from at least three biological and analytical replicates. Maximum efficacy was normalized to vehicle (0%) and no cells (100%). NA = not applicable; NI = no inhibition.