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Pharmacokinetics of 37da
| dose (mg/kg) | T1/2 (h) | Tmax (m) | Cmax (ng/mL) | AUClast (h ng/mL) | AUCInf (h ng/mL) | AUCExtrapobs % | MRTInfobs (h) | AUClast/D (ng/mL) | F (%) | |
|---|---|---|---|---|---|---|---|---|---|---|
| Plasma | 50 p.o. | 4.48 | 1.00 | 413 | 1678 | 2292 | 26.8 | 6.05 | 33.6 | 21.9 |
| Brain | 50 p.o. | 1.00 | 635 | 2106 | 3450 | |||||
| Plasma | 5 i.v. | 1.68 | 1592b | 766 | 778 | 1.52 | 1.07 | 153 |
PK parameters from measurements at 0.25, 0.5, 1, 2, 4, 8 and 24 h (N = 5).
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