Table 4.

Heat Map of IC₅₀ Values (μM) for New-Generation Peptides against a Broader Panel of HIV Env-Pseudotyped Strains

	R5a					R5/X4a	X4a
Peptide	YU2b	BaL26b	JRFLb	JRCSFb	SF162b	89.6b	HxB2b	NL4–3b
2Cc	30	65	NDd	NAd	NAd	NAd	54	53
16–2	5	NDd	NDd	NDd	NDd	NAd	167	44
18–2	1.9	27	NDd	NDd	NDd	132	72	12
20–2	0.42	14	56	NAd	NAd	13	>50	8
20–5	0.72	9.5	75	NAd	NAd	7	>100	6
30–2	0.96	6	8	47	24	0.57	21	4
40–2	0.26	21	35	91	69	27	40	17

^aVirus tropism. R5, R5/X4, and X4 are CCR5-, dual-, and CXCR4-tropic strains, respectively. Neutralization assays were performed as described previously.⁹

^bHIV strain.

^cReference 5.

^dIC₅₀ (μM) key: red, <1; orange, <15; yellow, ≤40; green, ≤100; white, >100 or ND, not determined; gray, NA, not active at ≤500 μM.