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. Author manuscript; available in PMC: 2020 May 31.
Published in final edited form as: Bioorg Med Chem. 2016 Mar 3;24(8):1718–1728. doi: 10.1016/j.bmc.2016.02.044

Table 2.

HIV neutralization activity of trisulfonaphthyl moleculesa

graphic file with name nihms-1592625-t0010.jpg
Compound R1 R2 IC50 (μM)
YU2 JRCSF HxB2
9a Me Ph NAb 47.6 36.8
9b Me 4-CF3-Ph 91.9 26.1 19.7
9c Me 4-OMe-Ph 47.6 27.0 22.5
9d Ph Ph 148.1 35.5 29.3
9e Ph 4-OMe-Ph 80.8 32.3 18.7
9f Ph 4-CF3-Ph 80.6 30.8 28.9
a

HIV-1 strains include CCR5-tropic strains YU2 and JRCSF and CXCR4-tropic strain HxB2.

b

NA, not active at concentrations as high as 400 μM.