Skip to main content
. Author manuscript; available in PMC: 2020 May 31.
Published in final edited form as: Bioorg Med Chem. 2016 Mar 3;24(8):1718–1728. doi: 10.1016/j.bmc.2016.02.044

Table 4.

Combination effects of disulfonate inhibitors and sulfated CCR5 Nt(2–18)

Inhibitor Combination
ratioa 		Dose reduction index
(DRI)		 Combination index (CI)b
Inhibitor:
Nt(2–18)		 Inhibitor Nt(2–18)
11d 1:10 1.3 ± 0.4 1.3 ± 0.4 2.3
11i 1:10 1.2 ± 0.4 1.7 ± 0.5 1.9
11j 1:10 1.2 ± 0.4 1.1 ± 0.3 2.5
a

The ratio of inhibitor concentrations approximates the ratio of the IC50 values of the inhibitors alone.

b

The CI represents the combined effect of two inhibitors in combination where CI values <1, 1 and >1 correspond to synergistic, additive and antagonistic effects, respectively.