Figure 3.

Effector granules or cytokine expressions at the third week of illness according to severity. (A) Perforin or granzyme B expressions in severe (n = 4, open circle) and mild cases (n = 8, closed circle) and representative dot plots showing the identification of perforin⁺, granzyme B⁺, IL-7Rα^high, or IL-7Rα^low cells in CD4⁺ or CD8⁺ T cells in severe (upper panels) or mild (lower panels) cases. (B) Frequencies of IL-7Rα^low effector memory (CCR7-CD45RA^+/−) CD8⁺ T cells and representative histograms. (C) IFN-γ, IL-2, IL-4, and IL-17 expressions in CD4⁺ and CD8⁺ T cells and representative dot plots showing the identification of IFN-γ⁺, IL-2⁺, IL-4⁺, and IL-17⁺ cells in CD4⁺ or CD8⁺ T cells in severe (upper panels) or mild (lower panels) cases. Bars denote mean values. Gray boxes represent interquartile ranges of healthy controls.