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. 2019 Mar 18;11(12):1056–1068. doi: 10.1093/jmcb/mjz002

Figure 6.

Figure 6

Morphine interrupts the recognition of autophagosomes to the damaged mitochondria and suppresses the infusion of damaged mitochondria to lysosomes. (A) SH-SY5Y cells expressing RFP-LC3 were stimulated with rotenone (100 nM) for 6 h, in the presence or absence of morphine (200 μM) for 24 h, and then stained with Mitotracker green for mitochondria. (B) SH-SY5Y cells were stimulated with rotenone (100 nM) for 6 h, in the presence or absence of morphine (200 μM) for 24 h, and then stained with Mitotracker green for mitochondria and Lysotracker red for lysosomes. (C) SH-SY5Y cells expressing GFP-LC3 were stimulated with rotenone (100 nM) for 6 h, in the presence or absence of morphine (200 μM) for 24 h, and then stained with Lysotracker red for lysosomes. Scale bar, 10 μm.