Table 1.
Baseline characteristics and outcomes among 155 women with 179 β-hCG confirmed pregnancies enrolled in the Environment and Reproductive Health Study (EARTH) between 2004 and 2015.
| Characteristic | Total Cohort (N=155) N (%) |
|---|---|
| Age at study entry (years) | |
| Mean (SD) | 34.9 (3.6) |
| Min-Max | 27–42 |
| Age > 35 | 64 (41%) |
| BMI (kg/m2) | |
| Mean (SD) | 23.6 (4.0) |
| Min-Max | 16–37 |
| Overweight or obese (≥25) | 46 (30%) |
| Educationa | |
| < College graduate | 8 (5%) |
| College graduate | 52 (34%) |
| Graduate degree | 85 (55%) |
| Smoking | |
| Never smoked | 120 (77%) |
| Ever smoked | 35 (23%) |
| Race | |
| Caucasian | 135(87%) |
| Black/African American | 2 (1%) |
| Asian | 14 (9%) |
| Other | 4 (3%) |
| Nulligravida | 100 (65%) |
| Nullipara | 134 (87%) |
| Primary SART diagnosis | |
| Female factor | 44 (28%) |
| Diminished ovarian reserve | 7 (4%) |
| Ovulation disorders | 17 (11%) |
| Endometriosis | 8 (5%) |
| Uterine disorders | 2 (1%) |
| Tubal factor | 10 (6%) |
| Male factor | 60 (39%) |
| Unexplained | 51 (33%) |
| FSH Day 3 in IU/L | |
| Mean (SD) | 6.9 (2.1) |
| Pregnancy Loss Outcomesb,c,d | |
| Biochemical Loss | 21 (12%) |
| Loss <20 weeks | 56 (31%) |
Abbreviations: Body Mass Index (BMI); Standard Deviation (SD); Minimum (Min); Maximum (Max); Follicle Stimulating Hormone (FSH, measured in serum on day 3); Society for Assisted Reproductive Technology (SART) primary diagnosis at study entry.
Unknown/missing education values: n=10.
Pregnancy was defined as two or more serum β-hCG levels >= 6 mIU/mL. Biochemical pregnancy loss was defined as the demise of a non-visualized β-hCG confirmed pregnancy. Pregnancy loss <20 weeks gestation was defined as the loss of any pregnancy (including biochemical losses) of less than 20 weeks gestation (<=139 days).
Proportion of pregnancy loss outcomes in total number of pregnancies (n/179).
Biochemical pregnancy losses by quartile of the sum of organophosphate flame retardant concentrations (ΣPFR): 4/44 (9%); 6/45 (13%); 4/45 (9%); 7/45 (16%); Total losses by quartile of ΣPFR: 12/44 (27%); 17/45 (38%); 13/45 (29%); 14/45 (31%).