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. Author manuscript; available in PMC: 2021 Mar 15.
Published in final edited form as: Stat Med. 2019 Dec 4;39(6):801–813. doi: 10.1002/sim.8446

Table 2.

Association results of gene by smoking interaction on continuous trait: BMI and binary trait: overweight status (BMI ≥ 25) for two previously identified loci using the Framingham Heart Study

Gene Chromosome # of variants used famGE p-value Burden test p-value
Continuous: BMI
CHRNB4 15 8 0.0063 0.3787
INPP4B 4 5 0.5504 0.7797
Binary: BMI ≥ 25
CHRNB4 15 8 0.0023 0.0184
INPP4B 4 5 0.9166 0.9952

# of variants used refer to functionally relevant variants (stop-gain/loss, splice, or missense) that were included in famGE test