Table 2.
Changes of biomarkers during hospitalization in patients with acute heart failure with preserved left ventricular ejection fraction and heart failure with reduced left ventricular ejection fraction
| HFPEF | HFREF | Difference in percent change between groups | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | Admission | Discharge | P | n | Admission | Discharge | P | P | |
| Markers of cardiovascular stress and congestion: | |||||||||
| BNP (pg/mL) | 19 | 848 [414–1577] | 228 [161–520] | <0.001 | 19 | 989 [901–3039] | 313 [194–598] | <0.001 | 0.67 |
| MR‐proANP (pmol/L) | 34 | 386 [267–626] | 362 [230–502] | 0.02 | 25 | 515 [305–737] | 376 [254–587] | 0.003 | 0.41 |
| sCD146 (ng/mL) | 34 | 509 [379–624] | 420 [320–519] | 0.01 | 24 | 606 [448–705] | 483 [423–590] | 0.12 | 0.96 |
| hsTnI (pg/mL) | 34 | 29 [16–75] | 19 [10–66] | 0.03 | 20 | 45 [21–111] | 31 [15–89] | 0.20 | 0.89 |
| Markers of inflammation and fibrosis | |||||||||
| Soluble ST2 (ng/mL) | 34 | 81 [61–131] | 50 [40–59] | <0.001 | 25 | 89 [59–133] | 41 [33–53] | <0.001 | 0.46 |
| CRP (mg/L) | 34 | 11.8 [4.7–37.3] | 10.7 [6.4–34.4] | 0.86 | 24 | 8.0 [3.8–17.9] | 4.0 [2.5–27.9] | 0.14 | 0.37 |
| Procalcitonin (ng/mL) | 32 | 0.11 [0.08–0.14] | 0.10 [0.07–0.14] | 0.34 | 24 | 0.10 [0.08–0.17] | 0.11 [0.07–0.17] | 0.75 | 0.60 |
| Biological markers of renal function: | |||||||||
| Creatinine (mg/dL) | 34 | 1.05 [0.87–1.39] | 1.05 [0.79–1.90] | 0.17 | 25 | 1.27 [1.05–1.60] | 1.34 [1.13–1.64] | 0.46 | 0.35 |
| eGFR (mL/min/1.73m2) | 34 | 59 [40–74] | 56 [36–74] | 0.19 | 25 | 59 [45–76] | 56 [41–68] | 0.41 | 0.35 |
| Cystatin C (mg/L) | 33 | 1.55 [1.23–2.35] | 1.92 [1.51–2.73] | 0.002 | 24 | 1.40 [1.14–1.83] | 1.49 [1.30–1.88] | 0.002 | 0.46 |
| Urea nitrogen (mmol/L) | 33 | 8.9 [6.8–12.3] | 10.2 [7.5–16.0] | 0.02 | 24 | 8.5 [7.2–14.1] | 10.4 [7.9–16.4] | 0.16 | 0.99 |
| Uric acid (μmol/L) | 33 | 358 [331–476] | 478 [343–544] | <0.001 | 24 | 449 [394–679] | 481 [401–635] | 0.95 | 0.01 |
| NGAL (ng/mL) | 32 | 176 [104–273] | 217 [111–273] | 0.02 | 22 | 107 [85–147] | 132 [84–188] | 0.09 | 0.97 |
| Markers of plasma volume: | |||||||||
| Haemoglobin (g/dL) | 27 | 12.2 [10.9–13.3] | 11.5 [11.0–12.4] | 0.10 | 26 | 13.5 [12.5–14.4] | 13.1 [11.9–13.9] | 0.14 | 0.75 |
| Haematocrit (%) | 27 | 37 [35–40] | 35 [34–38] | 0.08 | 26 | 41 [38–44] | 39 [37–43] | 0.12 | 0.63 |
| Estimated plasma volume | 27 | 5.2 [4.5–5.9] | 5.7 [5.1–6.2] | 0.12 | 26 | 4.3 [3.9–4.9] | 4.7 [4.1–5.1] | 0.16 | 0.71 |
AHF, acute heart failure; BNP, B‐type natriuretic peptide, CRP: C‐reactive protein; eGFR, estimated glomerular filtration rate; HFPEF, heart failure with preserved left ventricular ejection fraction; hsTnI, high sensitive troponin I; MR‐proANP, mid‐regional pro‐atrial natriuretic peptide; NGAL, neutrophil gelatinase associated lipocalin; sCD146, soluble cluster of differentiation 146; ST‐2, suppression of tumorigenecity‐2.
Data are presented as median [interquartile range]. Bold numbers mean statistically significant.