Table 1.
Demographics, bioluminescence and fluciclovine uptake in PC3-Luc xenografts injected with BCH, MeAIB or saline
| Substrate injected (mouse) |
Mouse size (gm) | Tumor size (mm) | Fluciclovine dose injected (μci) | Bioluminescence | |
|---|---|---|---|---|---|
| Total flux (p/s) | Average radiance (p/s/cm2/ sr) | ||||
| BCHa (1) | 28 | 12 × 9.0 | 128 | 5.43E+08 | 1.38E+07 |
| BCH (2) | 27.4 | 7.6 × 9.0 | 131 | 1.75E+08 | 4.50E+06 |
| BCH (3) | 27.5 | 4.8 × 5.2 | 141 | 2.47E+07 | 5.12E+05 |
| BCH (4) | 27 | 5.2 × 5.7 | 130 | 3.15E+07 | 1.21E+06 |
| BCH (5) | 30.3 | 6.7 × 6.3 | 128 | 2.61E+08 | 6.36E+06 |
| BCH (6) | 30 | 6.0 × 6.3 | 123 | 1.45E+07 | 4.83E+05 |
| MeAIBb (1) | 26.3 | 5.6 × 5.0 | 113 | 1.15E+08 | 2.93E+06 |
| MeAIB (2) | 26.9 | 6.1 × 8.9 | 110 | 9.37E+07 | 2.37E+06 |
| MeAIB (3) | 28.2 | 6.0 × 5.0 | 141 | 7.80E+06 | 3.27E+05 |
| MeAIB (4) | 28.8 | 6.5 × 7.2 | 122 | 8.62E+07 | 3.31E+06 |
| MeAIB (5) | 30 | 8.2 × 7.9 | 122 | 2.48E+08 | 5.66E+06 |
| Saline (1) | 25 | 7.6 × 6.6 | 137 | 1.32E+08 | 3.35E+06 |
| Saline (2) | 26.6 | 6.6 × 7.1 | 130 | 3.90E+07 | 1.41E+06 |
a
BCH-2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid
b
MeAIB-alpha-(methylamino)isobutyric acid