Table 1.
Demographic and baseline clinical characteristics, and associated survival.
| Survival | |||
|---|---|---|---|
| Characteristic | N = 36 n (%) | Day 42 n (%)a | Day 84 n (%)a |
| Age, years: | |||
| Median (range) | 51 (3–82) | NA | NA |
| <18 | 3 (8.3) | 3 (100) | 3 (100) |
| Male sex | 21 (58.3) | 14 (66.7) | 13 (61.9) |
| Underlying conditions: | |||
| Hematologic malignancy | 17 (47.2) | 12 (70.6) | 9 (52.9) |
| Allogeneic HCT | 5 (13.9) | 3 (60.0) | 2 (40.0) |
| Use of corticosteroids | 9 (25.0) | 9 (100) | 8 (88.9) |
| Neutropenia | 9 (25.0) | 7 (77.8) | 6 (66.7) |
| Diabetes mellitus | 5 (13.9) | 4 (80.0) | 4 (80.0) |
| Solid organ transplant | 3 (8.3) | 3 (100) | 2 (66.7) |
| Penetrating trauma | 2 (5.6) | 2 (100) | 2 (100) |
| Otherb | 4 (11.1) | 4 (100) | 4 (100) |
| None (at time of initial infection)c | 5 (13.9) | 4 (80.0) | 4 (80.0) |
Data are proportion (%) of patients, unless otherwise specified. Underlying condition counts total to more than 36, because patients may have more than one underlying condition.
HCT = hematopoietic stem cell transplantation, NA = not applicable.
aPercentages are numbers of patients with the characteristic who were alive at day 42 or day 84/total numbers with the characteristic.
bIncludes one each of: cell-mediated immune deficiency (uncontrolled), Crohn's disease, interstitial lung disease, and systemic lupus erythematosus.
cIncludes patients who had infections caused by Cryptococcus gattii (three), Exophiala species (one), and Paracoccidioides brasiliensis (one).