Table 4.
Odds ratios (ORs) and 95% confidence intervals (CIs) for maternal occupational exposure to livestock or animal dust and offspring cancer risk, stratified by birth years of interest and exposure window.
| Cancer type | Births 1968–2016 | Births 1989–2016 | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pregnancy | Offspring birth to cancer diagnosis | Pregnancy | Offspring birth to cancer diagnosis | |||||||||||||
| N | % | ORa | ORb (95% CI) | N | % | ORa | ORb (95% CI) | N | % | ORa | ORb (95% CI) | N | % | ORa | ORb (95% CI) | |
| Controls | 1115 | 1.26 | 2344 | 2.25 | 567 | 1.20 | 1096 | 2.03 | ||||||||
| Leukemias | 14 | 0.97 | 0.70 | 0.71 (0.42–1.22) | 36 | 2.17 | 1.00 | 1.03 (0.73–1.44) | 7 | 0.88 | 0.69 | 0.70 (0.33–1.49) | 17 | 1.90 | 1.02 | 1.03 (0.63–1.69) |
| ALL | 10 | 0.87 | 0.63 | 0.65 (0.34–1.22) | 20 | 1.52 | 0.71 | 0.73 (0.46–1.14) | 5 | 0.80 | 0.61 | 0.61 (0.25–1.50) | 10 | 1.43 | 0.78 | 0.79 (0.42–1.49) |
| AML | <5 | 1.41 | - | 10 | 4.12 | 1.80 | 1.90 (0.98–3.67) | <5 | 1.63 | - | 5 | 3.73 | 1.81 | 1.87 (0.74–4.76) | ||
| CNS tumors | 16 | 1.19 | 1.01 | 1.00 (0.60–1.65) | 31 | 1.97 | 0.82 | 0.81 (0.57–1.17) | 9 | 1.24 | 1.01 | 0.97 (0.49–1.90) | 7 | 0.85 | 0.38 | 0.36 (0.17–0.78) |
| Astrocytoma | 10 | 2.39 | 1.87 | 1.83 (0.95–3.54) | 11 | 2.18 | 0.83 | 0.82 (0.45–1.51) | 7 | 3.17 | 2.65 | 2.58 (1.14–5.81) | <5 | 1.58 | - | |
| Medulloblastoma | <5 | 1.81 | - | <5 | 1.06 | - | <5 | 1.27 | - | <5 | 1.11 | - | ||||
| Bone tumors | 5 | 2.19 | 1.53 | 1.81 (0.72–4.57) | 6 | 2.19 | 0.81 | 0.83 (0.36–1.90) | <5 | 1.72 | - | <5 | 2.19 | - | ||
| Germ cell tumor | <5 | 1.21 | - | 5 | 2.51 | 1.07 | 1.15 (0.46–2.87) | <5 | 1.19 | - | <5 | 4.12 | - | |||
| Neuroblastoma | <5 | 1.45 | - | 8 | 2.73 | 1.73 | 1.72 (0.83–3.59) | <5 | 1.32 | - | 6 | 3.80 | 2.33 | 2.29 (0.97–5.44) | ||
| Retinoblastoma | 5 | 4.03 | 2.87 | 2.67 (1.01–7.03) | <5 | 3.20 | - | <5 | 3.95 | - | <5 | 3.85 | - | |||
| Rhabdomyosarcoma | <5 | 0.00 | - | <5 | 0.65 | - | <5 | 0.00 | - | <5 | 0.00 | - | ||||
| Wilms tumors | <5 | 1.46 | - | <5 | 0.43 | - | <5 | 0.93 | - | <5 | 0.00 | - | ||||
a
Crude odds ratios.
b
Odds ratios adjusted for maternal age (continuous).