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Changes in cathepsin B charge states at cytoslic compared to lysosomal pH conditons
| Enzyme Domain | Charge State: | |
|---|---|---|
| pH 4.6 (lysosome) | pH 7.2 (cytosol) | |
| Cathepsin B, mature | + 9.5 | − 10.3 |
| Occluding loop | + 2.2 | − 0.9 |
Estimated charge states for human cathepsin B and its occluding loop domain were calculated using Protein Calculator 3.4 (http://protcalc.sourceforge.net/)
