Table 4.
Top networks associated with A) pre-pregnancy BMI and B) trimester specific gestational weight gain
| Networks | Molecules in Network | Score | Molecules | Top Diseases and Functions |
|---|---|---|---|---|
| Pre-pregnancy BMI | ||||
| 1 | ANTXR1, Akt, CD3, Ck2, CollagentypeI, CollagentypeIV, DICER1, DNMT3L, EPAS1, ERK, ERK1/2, GPAM, GSN, HCAR1, Histoneh3, INPP4B, ITGB1BP1, Insulin,MAFK, MMP15, MYO16, NRF1, PI3K(complex), PTPRJ, RAB27B, RASGRF1, RIMS2, SCNN1B, SEC14L1, SLITRK1, TBX1, TNFRSF8,cytokine, estrogen receptor, mir-26 | 55 | 23 | Connective Tissue Disorders, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders |
| 2 | AFF3, AFF4, ANKFY1, Atp5e, CHPF, CTDSPL, Cyb5r3, DENND3, EIF3B, FAM13C, FANCD2, KIAA1324, LRRC45, Lrrfip2, MED12L, MED19, MED30, MED4, MOB2, MPP4, NFkB (complex), NMRAL1, NUMBL, PDX1, PLEKHM2, POLN, SASH1, SDCBP2, ST18, ST3GAL1, Slc25a1, TMX2, UNC5CL, WRN, ZC3H13 | 32 | 15 | Cell Cycle, Cellular Assembly and Organization, DNA Replication, Recombination, and Repair |
| 3 | ADPGK, AGAP3, AGBL5, AGO2, ANKRD11, C10orf71, CAMTA1, CFAP206, CNNM3, CTC1, DYRK1A, EGFL7, FAM219A, FBXL18, GPAT3, GSE1, HAO2, HM13, KAZN, KLHL29, LZTS2, PI4K2B, PIGQ, QPCTL, RASAL2, SH3BP5L, SHPK, SLC25A13,SMG6, TMCO3, TRIM25, TROAP, ZMAT2, miR-589-5p (and other miRNAs w/seed GAGAACC), mir-589 | 29 | 14 | Developmental Disorder, Hereditary Disorder, Metabolic Disease |
| 4 | ALDH4A1, ALLC, ARRB1, ATP5F1D, Atp5k, C1orf116, CAPS, CDH1, CMTM8, COG7, DBH-AS1, DPP10, ESR1, Erk1/2 dimer, FAM160B2, FGF1, FGF22, IFNB1, LINC-ROR, LRRC17, MAPK3, MRPL1, Mta, Ndocosahexaenoylethanolamine, NAA16, PANK1, PXYLP1, RBBP9, SMAD2, TP53, TSKU, VEZT, goralatide,lewis Y, miR-515-5p (and other miRNAs w/seed UCUCCAA) | 21 | 11 | Cancer, Hereditary Disorder, Organismal Injury and Abnormalities |
| GWG1 | ||||
| 1 | ALLC, CD163L1, CGREF1, DLX5, Dlx6os1, Eda, GPR19, GPR85, HENMT1, HOOK1, IL17D, IL4, Ighg3, KIF3A, Ltbp, MFAP4, MIR155HG, MN1, MPV17L, MYT1L, N-arachidonoyl-dopamine, NFkB (complex), PPP4R3A, SLC2A6, SMARCA4, SMG7, Srrm2, TGFB1, TP53, Tnfrsf22/Tnfrsf23, ZNF385A, miR-515-3p (and other miRNAs w/seed AGUGCCU), mir-584, neopterin,sesamol | 17 | 6 | Cell Cycle, Cellular Development, Cellular Growth and Proliferation |
| 2 | DHDDS, FOXP4, HNF4A, LOX, MT-ND1, NPC2, NUS1, ditrans, polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific], dolichol monophosphate | 3 | 1 | Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism |
| GWG2 | ||||
| 1 | ADAMTS8, AP3B1, C16dihydroceramide, CCDC88B, CD163L1, CEACAM3, CHI3L2, Ccl27a, FCGR1B, FRMD4A, H60a,IFNG, IL17D, IL1F10, LILRA4, MTHFD2L, MYT1L, Myhs, NR4A1, RFX1, Raet1b, SCUBE1, SCUBE2, SLC28A1, SLC28A2, TNF, TRDV2, TREM3, TRIL, Trbv13-1,d18:0/24:0 dihydroceramide, neopterin, palmitoylsphingomyelin, ubiquinone 9, vanillic acid | 13 | 5 | Drug Metabolism, Molecular Transport, Nucleic Acid Metabolism |
| 2 | IL7R, SLC35F3 | 3 | 1 | Cell Cycle, Cell Death and Survival, Cellular Function and Maintenance |
| 3 | DEPDC1B, EBPL, GLP1R, KMT2D, NLGN3, NPM1 | 3 | 1 | Cell Morphology, Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization |
| GWG3 | ||||
| 1 | ADAM19, ARHGEF17, BPGM, BUD23, DNAJC13, EBPL, EGR2, EMG1, FAU, FRMD4A, Foxo, GFRA2, GZMM, HSPA12A, HSPA13, Hnrnpa1, IL17D, IL17RD, IL1RL2, IL7R, ITGAE, Lymphotoxin, MR1, NPM1, NPM3, NRTN, OGN, POU3F2, RPL29, RPL7L1, SH3TC2, SLAMF6, SLC35F3, TNF, ZNF750 | 15 | 5 | Cell Morphology, Cellular Assembly and Organization, Cellular Development |
Abbreviations: Pre-pregnancy BMI, Body Mass Index, GWG1, Rate of Gestational weight gain at 1st trimester; GWG2, Rate of Gestational weight gain at 2nd trimester; GWG3, Rate of Gestational weight gain at 3rd trimester