Table 2. Kidney Donor Vital Signs and Laboratory Values at Baseline and 20 hours after Brain Death.
Data presented as average values ± SD. Vital signs were monitored throughout the BD period, no clinically significant differences were detected for any parameters between groups at any of the time points investigated. Body temperature was monitored in degrees Farenheit (°F).
| Baseline | T=1200 minutes (20 hours) | |||||||
|---|---|---|---|---|---|---|---|---|
| Parameter | Group 1 Vehicle | Group 2 rhC1INH + heparin | Group 3: Heparin | P Value | Group 1 Vehicle | Group 2 rhC1INH + heparin | Group 3: Heparin | P Value |
| Vitals, mean ± SD | ||||||||
| Temperature, ◦F | 98.7 ± 1.8 | 95.8 ± 1.7 | 97.9 ± 1.8 | 0.226 | 98.7 ± 1.4 | 98.6 ± 1.8 | 99.9 ± 0.2 | 0.614 |
| Pulse, bpm | 138.3 ± 24.7 | 139.3 ± 18.6 | 125.0 ± 14.1 | 0.726 | 156.7 ± 28.0 | 150.7 ± 33.6 | 134.0 ± 8.5 | 0.686 |
| MAP, mmHg | 70.0 ± 6.2 | 78.3 ± 8.5 | 52.5 ± 24.7 | 0.184 | 64.0 ± 16.1 | 77.7 ± 6.4 | 59.5 ± 0.7 | 0.234 |
| UOP, mL/kg/h | NA | 3.3 ± 0.8 | 4.9 ± 3.9 | 12.2 ± 7.6 | 0.149 | |||
| Metabolic panel , mean ± SD | ||||||||
| Na, mmol/L | 147.3 ± 2.3 | 146.3 ± 1.5 | 148.5 ± 0.7 | 0.465 | 143.7 ± 2.9 | 150.0 ± 4.4 | 157.5 ± 0.7 | 0.016 |
| K, mmol/L | 3.5 ± 0.4 | 3.5 ± 1.3 | 3.3 ± 0.0 | 0.945 | 3.6 ± 0.5 | 2.9 ± 0.3 | 3.2 ± 0.1 | 0.151 |
| Cl, mmol/L | 111.3 ± 2.3 | 109.3 ± 1.2 | 111.0 ± 1.4 | 0.406 | 107.7 ± 2.9 | 112.0 ± 5.2 | 119.5 ± 2.1 | 0.053 |
| CO2, mmol/L | 23.7 ± 0.6 | 26.0 ± 1.0 | 24.0 ± 2.8 | 0.211 | 22.3 ± 2.5 | 23.7 ± 3.1 | 23.0 ± 2.8 | 0.849 |
| BUN, mg/dL | 18.0 ± 1.7 | 14.7 ± 4.0 | 21.5 ± 0.7 | 0.107 | 16.7 ± 5.5 | 13.3 ± 8.6 | 8.5 ± 0.7 | 0.446 |
| Cr, mg/dL | 0.7 ± 0.2 | 0.4 ± 0.1 | 0.6 ± 0.0 | 0.064 | 0.8 ± 0.1 | 0.5 ± 0.2 | 0.5 ± 0.1 | 0.031 |
| Glc, mg/dL | 68.3 ± 5.5 | 84.3 ± 16.9 | 61.0 ± 8.5 | 0.167 | 117.0 ± 37.3 | 106.7 ± 41.7 | 135.5 ± 2.1 | 0.690 |
| CBC , mean ± SD | ||||||||
| Hb, g/dL | 12.6 ± 0.4 | 13.0 ± 1.2 | 11.7 ± 4.1 | 0.775 | 9.3 ± 2.0 | 10.6 ± 0.9 | 11.6 ± 1.9 | 0.382 |
| Hct, % | 37.0 ± 1.0 | 38.3 ± 3.5 | 34.5 ± 12.0 | 0.782 | 27.3 ± 5.9 | 31.0 ± 2.6 | 34.0 ± 5.7 | 0.374 |
| ABG, mean ± SD | ||||||||
| pH | 7.4 ± 0.0 | 7.3 ± 0.0 | 7.3 ± 0.1 | 0.468 | 7.3 ± 0.1 | 7.4 ± 0.1 | 7.3 ± 0.1 | 0.181 |
| pCO2, mmHg | 49.7 ± 14.1 | 49.1 ± 6.8 | 49.3 ± 3.9 | 0.997 | 50.2 ± 11.8 | 35.7 ± 10.7 | 47.3 ± 11.7 | 0.344 |
| pO2, mmHg | 478.7 ± 115.0 | 323.0 ± 138.3 | 401.5 ± 41.7 | 0.336 | 288.7 ± 169.4 | 258.3 ± 115.5 | 272.5 ± 40.3 | 0.961 |
| HCO3, mmol/L | 26.0 ± 1.2 | 26.3 ± 1.1 | 25.4 ± 0.9 | 0.675 | 23.6 ± 3.1 | 27.7 ± 9.8 | 22.6 ± 2.5 | 0.661 |
| Lac, mmol/L | 0.5 ± 0.2 | 0.3 ± 0.0 | 0.4 ± 0.2 | 0.639 | 0.5 ± 0.2 | 0.8 ± 0.4 | 0.6 ± 0.0 | 0.629 |
ABG, arterial blood gas; BPM, beats per minute; BUN, blood urea nitrogen; CBC, complete blood count; Cr, creatinine; Glc, glucose; Hb, hemoglobin; Hct, hematocrit; Lac, lactate; MAP, mean arterial pressure; UOP, urine output.