Skip to main content
. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Mar 14;1867(7):118703. doi: 10.1016/j.bbamcr.2020.118703

Figure 11: Fibroblasts harvested from FS3KO hearts exhibit attenuated synthesis of ECM genes.

Figure 11:

When compared with Smad3 fl/fl cardiac fibroblasts, FS3KO fibroblasts had significantly lower mRNA expression of Col2a1(C), Col4a1 (G), Col4a2 (I), Thrombospondin-1/Thbs1 (M) and TIMP3 (O), and exhibited trends towards reduced expression of Col1a1 (A), Col3a1 (E) and Col5a1 (K). In contrast, when compared with corresponding Smad2 fl/fl controls, fibroblasts harvested from FS2KO hearts had comparable expression of Col1a1 (B), Col2a1 (D), Col3a1 (F), Col4a1 (H), Col4a2 (J), Col5a1 (L) and TIMP3 (P). Thbs1 levels were significantly reduced in the absence of Smad2 (N). n=4/group. Unpaired t-test.