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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Mar 14;1867(7):118703. doi: 10.1016/j.bbamcr.2020.118703

Figure 3: Effects of Smad2 and Smad3 KD on fibroblast expression of basement membrane genes.

Figure 3:

Smad3 KD, but not Smad2 KD attenuated collagen IV a1 synthesis (A); however, effects on collagen IV a2 and collagen IV a3 gene expression did not reach statistical significance (B–C). Smad3 KD had no significant effects on laminin α1, α2 and β2 mRNA expression (D–F). In contrast, Smad2 KD significantly increased laminin α2 transcription (E) without affecting laminin α1 and β2 levels (D, F). (*p<0.05, **p<0.01, ***p<0.001 vs control (C), n=4/group, ANOVA followed by Dunnett’s multiple comparisons test).