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. Author manuscript; available in PMC: 2021 Jul 1.
Published in final edited form as: Biochim Biophys Acta Mol Cell Res. 2020 Mar 14;1867(7):118703. doi: 10.1016/j.bbamcr.2020.118703

Figure 5: Effects of Smad2 and Smad3 on fibroblast expression of ADAMTS and MMP family members.

Figure 5:

Smad3 KD significantly reduced Adamts1 (A) and Adamts5 (B) mRNA expression levels. In contrast, Smad2 KD had no effects on Adamts1 expression and accentuated Adamts5 synthesis (A–B). Smad2 KD increased expression of MMP1a (C), and MMP2 (D). In contrast, Smad3 KD had no effects on MMP1a expression, and reduced MMP2 levels (C–D). Smad2 and Smad3 KD significantly increased MMP14 expression (E). TIMP3 levels were markedly reduced following Smad3 KD (F). (*p<0.05, **p<0.01, ***p<0.001, vs. control (C), n=4/group, ANOVA followed by Dunnett’s multiple comparisons test).