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. 2020 May 27;13:4813–4824. doi: 10.2147/OTT.S237174

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© 2020 Mao et al.

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Knockdown of GAS6 expression inhibits proliferation, migration, and invasion of BCa cells. (A and B) GAS6 siRNA #1 is the most effective GAS6 knockdown among three siRNAs for UMUC-3 and T24 cells, as assessed by Western blot and qRT-PCR. (C) Specific GAS6 siRNA #1 was transfected into UMUC-3 and T24. (D and E) Silencing of GAS6 leads to significantly reduced proliferation of UMUC-3 and T24 cells compared to the si-NC group as assessed by CCK-8 and colony formation assay. (F and G) Transwell assays show GAS6 knockdown inhibits the migration and invasion of UMUC-3 and T24. Data are shown as mean ± SD. *Statistically significant (P < 0.05).