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. 2020 May 27;13:4813–4824. doi: 10.2147/OTT.S237174

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© 2020 Mao et al.

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GAS6 knockdown inhibitors proliferation and invasion of BCa cells by inactivating PI3K/AKT signaling pathway. (A–D) Bioinformatics analysis shows that the expression of the GAS6 gene is correlated with PIK3CA, PIK3CD, and PIK3CG (all P<0.05). (E) The role of GAS6 in PI3K/AKT signaling by Western blot. (F) Relative protein expression of each protein in UMUC-3 and T24 cells was quantified using Image-J software and normalized to GAPDH. (G) SC79 treatment partially restored the effect of GAS6 silencing on cell proliferation by CCK8 assays (all P<0.05). (H) Transwell assays revealed that SC79 treatment partially restored the effect of GAS6 silencing on cell invasion. Data are shown as mean ± SD. * Statistically significant (P < 0.05).