Table 3.
Univariable logistic regression: potential predictors of MCID in IIEF-EF at 6 months
| Total patients |
MCID in IIEF-EF at 6 months |
Or (95% CI) | P | ||||
|---|---|---|---|---|---|---|---|
| N | No |
Yes |
|||||
| N | % | N | % | ||||
| All | 80 | 38 | 47.5 | 42 | 52.5 | ||
| Group | |||||||
| Group A | 40 | 17 | 42.5 | 23 | 57.5 | 1.50 (0.62, 3.61) | .371 |
| Group B | 40 | 21 | 52.5 | 19 | 47.5 | Reference | |
| Age, in years | |||||||
| <60 | 58 | 25 | 43.1 | 33 | 56.9 | 1.91 (0.70, 5.16) | .204 |
| ≥60 | 22 | 13 | 59.1 | 9 | 40.9 | Reference | |
| 1-year increase | - | - | - | - | - | 0.97 (0.93, 1.01) | .104 |
| BMI (m/kg2) | |||||||
| 18.5–24.9 | 13 | 5 | 38.5 | 8 | 61.5 | 1.49 (0.39, 5.67) | .556 |
| 25–29.9 | 38 | 19 | 50.0 | 19 | 50.0 | 0.93 (0.35, 2.45) | .889 |
| ≥30 | 29 | 14 | 48.3 | 15 | 51.7 | Reference | |
| 18.5–24.9 | 13 | 5 | 38.5 | 8 | 61.5 | 1.55 (0.46, 5.24) | .478 |
| ≥25 | 67 | 33 | 49.3 | 34 | 50.7 | Reference | |
| HTN | |||||||
| No | 55 | 25 | 45.5 | 30 | 54.5 | 1.30 (0.50, 3.35) | .587 |
| Yes | 25 | 13 | 52.0 | 12 | 48.0 | Reference | |
| Dyslipidemia | |||||||
| No | 64 | 28 | 43.8 | 36 | 56.3 | 2.14 (0.69, 6.61) | .185 |
| Yes | 16 | 10 | 62.5 | 6 | 37.5 | Reference | |
| DM | |||||||
| No | 73 | 33 | 45.2 | 40 | 54.8 | 3.03 (0.55, 16.64) | .202 |
| Yes | 7 | 5 | 71.4 | 2 | 28.6 | Reference | |
| Hemoglobin A1C at baseline | |||||||
| Normal | 51 | 20 | 39.2 | 31 | 60.8 | 2.54 (0.99, 6.48) | .052 |
| Pre-diabetes/diabetes | 29 | 18 | 62.1 | 11 | 37.9 | Reference | |
| No. of comorbidities | |||||||
| 0 | 34 | 13 | 38.2 | 21 | 61.8 | 2.49 (0.70, 8.81) | .158 |
| 1 | 34 | 17 | 50.0 | 17 | 50.0 | 1.20 (0.29, 4.93) | .800 |
| 2+ | 12 | 8 | 66.7 | 4 | 33.3 | Reference | |
| Comorbidities Y or N | |||||||
| 0 | 34 | 13 | 38.2 | 21 | 61.8 | 2.22 (0.90, 5.49) | .083 |
| 1+ | 46 | 25 | 54.3 | 21 | 45.7 | Reference | |
| ED | |||||||
| Mild | 56 | 26 | 46.4 | 30 | 53.6 | 1.15 (0.44, 3.01) | .769 |
| Moderate | 24 | 12 | 50.0 | 12 | 50.0 | Reference | |
BMI = body mass index; HTN = hypertension; DM = diabetes mellitus; ED = erectile dysfunction; IIEF-EF = International Index of Erectile Function-Erectile Function domain; MCID = minimal clinically important difference; OR = odds ratio.
Pre-diabetes: HbA1C: 5.7–6.4%.
MCID was defined as increase in IIEF-EF total score of ≥2 for patients with baseline mild ED (baseline IIEF-EF score of 17–25), and ≥5 for patients with baseline moderate ED (score of 11–16).
95% CI: 95% CI for OR. P: P-value from Wald's test.
OR estimates from univariable logistic regression modeling the probability of MCID = “Yes” at 6 months.
A multivariable analysis was conducted testing all the variables listed in this table, using stepwise model selection with entry criteria of 50% and retention criteria of 10%. Given the small sample size and data sparseness, only A1C at baseline was retained in the model.