Table 1.
Summary of Metal Concentrations Evaluated for Dose Enhancement in Hypoxic Tumor
| Material | Injection Concentration [g/kg] | Metal Concentration Normoxic [g/kg] (Factor) | Metal Concentration Anoxic [g/kg] (Factor) | |
|---|---|---|---|---|
| GNP | Reduced | 1.35 | 1.35 (1) | 0.397 (1/3.4) |
| Zero | 1.35 | 1.35 (1) | 0 (0) | |
| CuATSM | Low | 0.1 | 0.0197 (0.197) | 0.177 (9) |
| Medium | 0.34 | 0.0672 (0.197) | 0.605 (9) | |
| High (Theoretical) |
1.35 | 0.27 (0.197) | 2.39 (9) | |
| Very High (Theoretical) |
6.85 | 1.35 (0.197) | 12.1 (9) | |
| Hybrid | Mix (Theoretical) |
1.35 (GNP) 2.6 (CuATSM) |
1.35 (GNP) | 4.68 (CuATSM) |
Abbreviations: GNP, gold nanoparticle; CuATSM, Cu(II) diacetyl-bis N4-methylthiosemicarbazone.