Fig. 5.

Electrophysiological characteristics in cardiomyocytes isolated from Lmna^H222P/H222Pmice

(A) Examples of action potentials (AP) recorded in wild type (WT) (black trace) and Lmna^H222P/H222P (red trace) cells. Membrane resting potential measured as the Zero current potential (left) and AP amplitudes (right) (B), maximum AP upstroke velocity (measured as dV/dt) (C), and AP duration (APD) at 20, 50, and 90% of repolarization. (D). The number of cardiomyocytes is indicated. Data are represented as the mean ± standard deviation of individuals. (t-test). (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)