Table 1.
Echocardiographic parameters for male LmnaH222P/H222P mice at 3, 4 and 5 months of age after AAV9-shSLN injection.
| Genotype | Treatment | n | Heart rate (beats/min) | LVEDD (mm) | LVESD (mm) | FS (%) |
|---|---|---|---|---|---|---|
| 3 months | ||||||
| Lmna WT | none | 5 | 317.2 ± 24.3 | 3.6 ± 0.1 | 1.9 ± 0.1 | 47.3 ± 0.4 |
| Lmna H222P | PBS | 5 | 346.2 ± 36.3 | 3.6 ± 0.1 | 2.0 ± 0.1 # | 43.5 ± 1.3 ## |
| Lmna H222P | shSLN | 5 | 286.0 ± 31.8 | 4.0 ± 0.3* | 2.3 ± 0.3 | 41.0 ± 4.8 |
|
Genotype |
Treatment |
n |
Heart rate (beats/min) |
LVEDD (mm) |
LVESD (mm) |
FS (%) |
| 4 months | ||||||
| Lmna WT | none | 5 | 367.0 ± 26.2 | 3.4 ± 0.2 | 1.8 ± 0.1 | 48.2 ± 0.7 |
| Lmna H222P | PBS | 5 | 326.4 ± 34.3 # | 3.8 ± 0.2### | 2.6 ± 0.2 ### | 32.3 ± 4.6 ## |
| Lmna H222P | shSLN | 5 | 331.4 ± 9.9 | 3.8 ± 0.1 | 2.2 ± 0.1 * | 40.5 ± 2.5 ** |
|
Genotype |
Treatment |
n |
Heart rate (beats/min) |
LVEDD (mm) |
LVESD (mm) |
FS (%) |
| 5 months | ||||||
| Lmna WT | none | 5 | 352.0 ± 32.8 | 3.7 ± 0.1 | 2.0 ± 0.1 | 45.5 ± 1.6 |
| Lmna H222P | PBS | 5 | 348.2 ± 25.2 | 3.9 ± 0.2 | 2.6 ± 0.2 ## | 33.9 ± 4.0 ## |
| Lmna H222P | shSLN | 5 | 313.8 ± 45.8 | 4.2 ± 0.5 | 3.0 ± 0.5 | 29.6 ± 5.2 |
Mean ± standard deviation are presented for each parameter, timepoint, genotype and treatment.
#P < 0.05, ##P < 0.01, ###P < 0.001 between PBS-injected LmnaH222P/H222P mice and wild type mice.
*P < 0.05, **P < 0.01 between PBS and shSLN-injected LmnaH222P/H222P mice. (ANOVA).