Table 1.
Summary of Knee Morphometry Parameters
| Single Injection1 | Three Injections1 | |||||||
|---|---|---|---|---|---|---|---|---|
| Vehicle (PBS) Control | IA-BioHA | Hylan G-F 20 | Vehicle (PBS) Control | IA-BioHA | ||||
| Mean (SE) | % Change2 | % Change2 | % Change2 | |||||
| Total tibial cartilage degeneration width (μm) | 1926.7 (17.9)2 | 1797.8 (54.0) | −7.6 | 1853.3 (50.3) | −4.3 | 1897.8 (22.4) | 1780. 0 (59.2) | −7.0 |
| Substantial tibial cartilage degeneration width (μm) | 653.3 (69.3) | 624.4 (63.3) | −4.4 | 693.3 (65.1) | 6.1 | 620.0 (69.9) | 573.3 (52.5) | −7.5 |
| Total cartilage degeneration score, 3-zone sum | 6.0 (0.5) | 5.73 (0.4) | −5.1 | 6.3 (0.5) | 4.4 | 6.2 (0.5) | 5.3 (0.4) | −15.4 |
| Total cartilage degeneration depth ratio, mean (μm) | 0.33 (0.03) | 0.32 (0.03) | −2.6 | 0.35 (0.03) | 4.6 | 0.34 (0.03) | 0.29 (0.03) | −14.6 |
| Femoral cartilage degeneration score | 2.3 (0.35) | 1.8 (0.24) | −20.2 | 2.8 (0.33) | 24.1 | 1.8 (0.28) | 1.3 (0.25) | −24.4 |
| Collagen width – total (μm) | 0.35 (0.02) | 0.36 (0.03) | −5.6 | 0.34 (0.02) | 0.5 | 0.37 (0.02) | 0.29 (0.02) | −20.7 |
Abbreviations: IA-BioHA Intra-articular biologically derived hyaluronic acid, PBS Phosphate buffered saline
1N = 15 animals/group. Results represent the mean (SE)
2Analysis of the percent change relative to vehicle control across all histopathology parameters demonstrated a statistically significant difference in the number of improved responses after a single (p < 0.0001) or three (p < 0.0001) weekly injections of IA-BioHA; the difference between vehicle control and a single injection of hylan G-F 20 was not significant