Table 4.
Characterisation of the available qAOP models based on the additional considerations listed in Table 1
References | Cross species extrapolation | Modulating factors | Feedback loops | Compensatory mechanisms | Test method adopted/validated | Kinetics | Exposure assessment | Uncertainty evaluation | Sensitivity analysis | Publicly available |
---|---|---|---|---|---|---|---|---|---|---|
Chu (2018) | – | √ | – | – | – | – | √ | √ | √ | √ |
Moe et al. (2018) | – | –– | – | – | √a | – | – | √ | √ | √ |
Jeong et al. (2018) | – | – | – | – | – | √ | – | – | √ | √ |
Burgoon et al. (2020) and Perkins et al. (2019a) | – | – | – | – | – | – | – | – | √ | √ |
Zgheib et al. (2019) | – | – | – | – | – | – | – | √ | √ | √ |
Yozzo et al. (2013) | – | – | – | – | – | – | – | – | – | – |
Muller et al. (2015) | – | – | – | – | – | √ | – | – | – | √ |
Margiotta-Casaluci et al. (2016) | – | – | √ | – | – | √ | – | – | √ | – |
Conolly et al. (2017) | – | – | √ | √ | – | √ | – | √ | – | – |
Hassan et al. (2017) | – | – | √ | √ | – | √ | √ | √ | – | √ |
Doering et al. (2018) | √ | – | – | – | – | – | – | √ | – | √ |
Battistoni et al. (2019) | – | √ | √ | – | – | – | √ | √ | – | – |
Doering et al. (2019) | √ | – | – | – | – | √ | – | √ | √ | – |
Foran et al. (2019) | – | – | – | – | – | – | – | – | – | – |
Zgheib et al. (2019) | – | – | – | – | – | – | – | √ | √ | √ |
aThe in vitro measurements were conducted on a plant recognised in the OECD test guidelines for toxicity testing of the endpoint