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. 2020 May 18;94(5):1497–1510. doi: 10.1007/s00204-020-02774-7

Table 4.

Characterisation of the available qAOP models based on the additional considerations listed in Table 1

References Cross species extrapolation Modulating factors Feedback loops Compensatory mechanisms Test method adopted/validated Kinetics Exposure assessment Uncertainty evaluation Sensitivity analysis Publicly available
Chu (2018)
Moe et al. (2018) –– a
Jeong et al. (2018)
Burgoon et al. (2020) and Perkins et al. (2019a)
Zgheib et al. (2019)
Yozzo et al. (2013)
Muller et al. (2015)
Margiotta-Casaluci et al. (2016)
Conolly et al. (2017)
Hassan et al. (2017)
Doering et al. (2018)
Battistoni et al. (2019)
Doering et al. (2019)
Foran et al. (2019)
Zgheib et al. (2019)

aThe in vitro measurements were conducted on a plant recognised in the OECD test guidelines for toxicity testing of the endpoint