Table 4.

Characterisation of the available qAOP models based on the additional considerations listed in Table 1

References	Cross species extrapolation	Modulating factors	Feedback loops	Compensatory mechanisms	Test method adopted/validated	Kinetics	Exposure assessment	Uncertainty evaluation	Sensitivity analysis	Publicly available
Chu (2018)	–	√	–	–	–	–	√	√	√	√
Moe et al. (2018)	–	––	–	–	√a	–	–	√	√	√
Jeong et al. (2018)	–	–	–	–	–	√	–	–	√	√
Burgoon et al. (2020) and Perkins et al. (2019a)	–	–	–	–	–	–	–	–	√	√
Zgheib et al. (2019)	–	–	–	–	–	–	–	√	√	√
Yozzo et al. (2013)	–	–	–	–	–	–	–	–	–	–
Muller et al. (2015)	–	–	–	–	–	√	–	–	–	√
Margiotta-Casaluci et al. (2016)	–	–	√	–	–	√	–	–	√	–
Conolly et al. (2017)	–	–	√	√	–	√	–	√	–	–
Hassan et al. (2017)	–	–	√	√	–	√	√	√	–	√
Doering et al. (2018)	√	–	–	–	–	–	–	√	–	√
Battistoni et al. (2019)	–	√	√	–	–	–	√	√	–	–
Doering et al. (2019)	√	–	–	–	–	√	–	√	√	–
Foran et al. (2019)	–	–	–	–	–	–	–	–	–	–
Zgheib et al. (2019)	–	–	–	–	–	–	–	√	√	√

^aThe in vitro measurements were conducted on a plant recognised in the OECD test guidelines for toxicity testing of the endpoint